Surgery Using Cartilage Scaffold Offers Hope For Horses With Chondritis

Two sets of arytenoid cartilage of the larynx keep a horse’s vocal folds together; they work together to open and close a horse’s airway. When this cartilage is damaged from an abscess, it can produce granular tissue protrudes into the airway. Severe cases can result in deformity and the inability to breathe well. Called chondritis, the condition is seen most often in young Thoroughbreds.

A recent study sought to determine if the damaged laryngeal cartilage could be replaced with a cartilage scaffold.  Published in Tissue Engineering (Part A), Drs. Marta Cercone, Bryan Brown, Elizabeth Stahl, Lisa Mitchell, Lisa Fortier, Hussni Mohammed and Norm Ducharme used a cartilage scaffold on eight affected horses. The cartilage had been treated to remove the cells, but left a cartilage matrix.

The scaffolds were then implanted into the defects in both arytenoid cartilages in the study horses. Before the scaffolds were implanted, one of each implant was seeded with bone marrow-derived nucleated cells (BMNC) that were collected from each recipient.

The scientists found that two months after the procedure that the cartilage matrix had become integrated into the horse’s arytenoid cartilage. Minimal adverse reactions were seen. The scaffolds that had been pre-seeded with BMNC broke down faster and were more rapidly incorporated into the recipient’s cartilage. They determined that replacing a portion of a horse’s arytenoid cartilage with a cartilage matrix that include BMNC is well tolerated and prevent laryngeal collapse during exercise.

Read more at Equine Science Update.

Read the article here.

The post Surgery Using Cartilage Scaffold Offers Hope For Horses With Chondritis appeared first on Horse Racing News | Paulick Report.

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