Resetting Receptors: Indian Herb Could Help Prevent Laminitis

A new study out of Queensland, Australia, shows that a traditional Indian herb may help hyperinsulinemic horses and ponies at risk of laminitis. Hyperinsulinemia occurs when too much insulin is produced in response to glucose.

The research team was searching for a way to reduce the large insulin response that happens after hyperinsulinemic horse eats a high-carbohydrate meal. Reported in PLOS ONE, the researchers used sweet taste receptor inhibitors to reduce the insulin and glucose responses to carbohydrates.

The team testes two inhibitors: lactisole and Gymnema sylvestre. Lactisole is carboxylic acid salt that suppresses the horse’s the ability to taste sweetness; G. sylvestre is used in traditional Indian medicine. Also called Australian cowplant, it supports balanced blood sugar and dulls the palate to sweets.

In a lab setting, lactisole reduced glucose uptake by 63 percent and G. sylvestre by 73 percent. Eight grade ponies were used as live models. After undergoing insulin and blood glucose baseline testing, it was determined that G. sylvestre was partially effective at reducing post-meal blood glucose and serum insulin concentrations. Lactisole was only effective in the lab and not on live ponies.

The research suggests that sweet taste receptor inhibitors may be useful in helping manage equine insulin dysregulation and prevent laminitis.

Read more at HorseTalk.

Read the full study here.


The post Resetting Receptors: Indian Herb Could Help Prevent Laminitis appeared first on Horse Racing News | Paulick Report.

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